uPAR
نویسندگان
چکیده
منابع مشابه
RhoB regulates uPAR signalling.
Urokinase-type plasminogen activator (uPA) and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion. Rho GTPases are key coordinators of these processes; the Rho GTPase Rac1 has previously been implicated in uPA- and/or uPAR-induced migratory or morphological cell responses. We used RNAi to deplete 12 different Rho GTPases to screen for effects on u...
متن کاملTwo signalling hands for uPAR.
doi:10.1160/TH13-01-0001 Thromb Haemost 2013; 109: 179 T&H Insight on ▶Montuori et al. Thromb Haemost 2013; 109: 309-318. Transmembrane proteins usually relay signals to the cytoplasm and nucleus via their intracellular domains. Nonetheless, this paradigm is challenged by glycosylphosphatidylinositol (GPI)-anchored proteins. Although completely extracellular, these proteins are linked to the li...
متن کاملAntagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration.
Interactions between urokinase plasminogen activator receptor (uPAR) and its various ligands regulate tumor growth, invasion, and metastasis. Antibodies that bind specific uPAR epitopes may disrupt these interactions, thereby inhibiting these processes. Using a highly diverse and naïve human fragment of the antigen binding (Fab) phage display library, we identified 12 unique human Fabs that bin...
متن کاملSPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferation.
Urokinase plasminogen activator receptor (uPAR) is a GPI anchored cell surface protein that is closely associated with invasion, migration, and metastasis of cancer cells. Many functional extracellular proteins and transmembrane receptors interact with uPAR. However, few studies have examined the association of uPAR with cytoplasm proteins. We previously used yeast two-hybrid screening to isola...
متن کاملTargeting uPAR with Antagonistic Recombinant Human Antibodies
Components of the plasminogen activation system, which are overexpressed in aggressive breast cancer subtypes, offer appealing targets for development of new diagnostics and therapeutics. By comparing gene expression data in patient populations and cultured cell lines, we identified elevated levels of the urokinase plasminogen activation receptor (uPAR, PLAUR) in highly aggressive breast cancer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2013
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.22124